Epithelial-mesenchymal transition in gastroenterological cancer

发表时间：2015-12-04 浏览次数：1431次

引用：

Okabe H, Mima K, Saito S, Hayashi H, Imai K, Nitta H, Hashimoto D, Chikamoto A,

关键词：

作者：

Hirohisa Okabe1, Kosuke Mima1, Seiya Saito1, Hirom

作者单位：

1 Department of Gastroenterological Surgery, Gradu

出版年份：

2015

期刊页数：

183-189

收录者：

其他外文数据库

摘要：

Epithelial-mesenchymal transition (EMT) was first reported as an essential process in embryonic cells and later showed that cancer cells, regardless of the context, exhibited a similar phenomenon that was crucial for tumor progression. Epithelial cells lose their adhesive characteristic capacity which is necessary for their functions but gain a mesenchymal phenotype. This change from epithelial to the mesenchymal phenotype of cancer cells makes it difficult to understand the mechanism underlying cancer biology and tumor progression. A number of transcription factors involved in tumor cell EMT and microRNA-regulated EMT have been reported. This review discussed recent findings and new players in EMT in gastrointestinal cancers. Since the molecular mechanisms of tumor progression are sometimes context-dependent, the recent findings of EMT have been reviewed in a context-dependent manner.

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