外用氨基酮戊酸光动力疗法联合CO2激光治疗肛管尖锐湿疣的疗效观察

发表时间：2015-03-24 浏览次数：1498次

引用：

伍健华,李常兴,韩春雷等.外用氨基酮戊酸光动力疗法联合CO2激光治疗肛管尖锐湿疣的疗效观察[J].吉林医学,2014,(19):4152-4153

关键词：

作者：

伍健华李常兴韩春雷

作者单位：

广东省东莞市慢性病防治院,广东东莞,523008

出版年份：

2014

期刊页数：

4152-4153

收录者：

知网,万方

摘要：

目的：观察外用氨基酮戊酸光动力疗法（ ALA-PDT）联合CO2激光治疗肛管尖锐湿疣的临床疗效。方法：84例肛管尖锐湿疣患者随机分为治疗组及对照组各42例，治疗组接受ALA-PDT联合CO2激光治疗，每周1次，连续3次，对照组接受CO2激光治疗，每周1次，连续3次。末次治疗后第1周进行疗效评价，第4、8和12周观察复发率。治疗前及末次治疗后1周进行实验室检查，并观察不良反应。结果：在末次治疗后1周，治疗组和对照组疣体清除率分别为100%和97.62%（ P>0.05）。治疗组治疗后总复发率（11.9%）明显低于对照组（35.71%）（P＝0.0104﹤0.05）。治疗组及对照组均未发生严重的不良反应，主要的不良反应包括红斑、疼痛、溃疡和疤痕等。结论：外用ALA-PDT联合CO2激光治疗肛管尖锐湿疣的治愈率高，复发率低，安全性好。 Objective To investigate the safety and efficacy of topical aminolevulinic acid photodynamic therapy( ALA-PDT)com-bined with carbon dioxide laser in the treatment of anal tube condyloma acuminatum. Method Eighty-four patients with anal tube condylo-ma acuminatum were randomly assigned to the treatment group and control group in an allocation ratio of 1:1. The treatment group was trea-ted with ALA-PDT combined with carbon dioxide laser weekly for 3 times. The control group was treated with carbon dioxide laser weekly for 3 times. The recurrence rate was evaluated at weeks 4,8,and l2 after the treatment ended. Results At l week after the last treatment 100% and 97. 62% of the base line warts were eliminated in the treatment group and the control group respectively( P>0. 05). The over-all recurrence rate of the treatment group was significantly lower than that in the control group( 11. 9% Vs 35. 7%,P=0. 010 4 ). There was no severe adverse event in either group. The main adverse event were mild symptoms including erythema,pain,ulcer and scar-ring. Conclusion Our results confirmed that ALA-PDT combined with carbon dioxide laser is an effective,safe and well-tolerated treat-ment for anal tube condylomata acuminata.

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