Allogeneic epidermal substitutes in the treatment of chronic diabetic leg and foot ulcers

发表时间：2015-12-08 浏览次数：1064次

引用：

Marchesi A, Brioschi M, Parodi PC, Marchesi M, Brambilla R, Vaienti L. Allogenei

关键词：

作者：

Andrea Marchesi1, Marco Brioschi1, Pier Camillo Pa

作者单位：

1 Department of Plastic and Reconstructive Surgery

出版年份：

2014

期刊页数：

74-80

收录者：

其他外文数据库

摘要：

Aim: Diabetic foot ulcers are the most common cause of nontraumatic lower extremity amputations in the industrialized world. Tissue-engineering products offer a lower extremity salvage strategy when healing does not proceed according to the standard of care. New allogeneic sheets are available for the management of diabetic leg and foot ulcers. Methods: The endpoints of this case series study regard preliminary outcomes of the application of allogeneic keratinocytes composed of benzyl ester of hyaluronic acid to 16 diabetic foot and leg ulcers in 11 patients with type 2 diabetes mellitus. Results: Between 21 and 70 days after cellular therapy, 6 out of 16 lesions were completely healed, reducing the wound dimension by 70% and improving the wound bed score by 52%. Conclusion: The clinical results of the new allogeneic sheets indicate that allogeneic keratinocytes may represent an effective and safe therapy for diabetic foot and leg ulcers in the multidisciplinary approach to this diabetes-related complication.

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